A Group of researchers report success in mice of a method using (PET) Positron Emission Tomography to scan and track the hormone receptor involved in prostate cancer.The investigators on this say, that this is a technique which such a antibody is used to detect and monitor prostate and other hormones sensitive cancers, and also to guide therapy in real time.
The paper of first author Danil Thorek,Ph.D.,Assistant professor of radiology and radiogical science at the Johns University School of Medicine,says that the agents can provide a unique way of disease progression in real time and in a noninvasive manner.
Mr.Thorek adds by saying that “we managed to accurately monitor the mouse prostate,and this research leads us to success, and soon we can easily come up with the treatment on people as well.The recent practice detects prostate cancer by tracking the androgen receptor by testing blood for prostate-specific antigen which is (PSA).If PSA is active this means that it may indicate prostate cancer is present in the body.Age and type of tumor are the various numerous factors through which PSA concentration in blood is affected.
so basically the attempt to target PSA with an antibody is complicated by washing out of the antibody -PSA complex,this is a process in which the complex is formed but does not remain near the disease.11B6 is a antibody which investigators developed to target the human kallikrein related peptidase 2(hk2),whereas hk2 is specifically active only in the prostate and an aggressive type of breast cancer.Through the process of binding free,unbound hk2 to 11B6, The research team found that newly formed 11B6-hK2 comlex is taken directly back into the cancerous cell rather than washed out.this is a biological process which relies on a transport mechanism involving the neonatal Fc receptor,in which cells are able to recognize and take in antibodies.
Through study on Cancer it has been declared that around 47,000 men are diagnosed with prostate cancer in the UK and 11,000 die from the disease.As cancer is spreading rapidly prostate cancer have been treated by cutting off the supply of testosterone or by blocking its effects and this is just considered similar to pouring petrol on a fire.Thus,laboratory experiments have hinted that blasting tumors with high level can also kill prostate cancer cells. our results are unexpected and exciting said by Professor Sam Denmeade, From Johns Hopkins University School of Medicine, in Baltimore,United States.